What is the recommended administration method for Aspirin in secondary prevention?

The recommended method for administering Aspirin in secondary prevention is through low-dose therapy. This approach is supported by numerous studies demonstrating that low doses of Aspirin effectively reduce the risk of recurrent cardiovascular events and complications in individuals who have already experienced heart attacks or strokes.

Low-dose Aspirin, typically around 75-100 mg per day, strikes a balance between maximizing the antiplatelet effects, which help prevent blood clots, and minimizing the risk of potential side effects, such as gastrointestinal bleeding. This dosing strategy is usually sufficient to inhibit platelet aggregation without exposing patients to the increased risks associated with higher doses.

In contrast, high doses might lead to greater side effects and complications without offering significant additional benefits for most patients in this context. Medium and variable doses lack the specific evidence supporting their efficacy and safety profile in secondary prevention, making them less ideal choices for patient management.