What is the recommended administration method for Verapamil to ensure optimal absorption?

Verapamil is best administered with food to enhance its absorption and mitigate potential gastrointestinal side effects. Taking the medication with food can lead to more consistent plasma levels, reducing the chances of fluctuations that might occur if taken on an empty stomach. This method helps to improve the bioavailability of the drug, which is crucial for its effectiveness in managing conditions such as hypertension or atrial fibrillation.

When Verapamil is taken without food, absorption may be inconsistent, potentially leading to inadequate therapeutic effects. Additionally, administering it at bedtime, while beneficial for certain medications, does not necessarily optimize absorption. Crushing and mixing Verapamil with water could alter its release characteristics and is not generally recommended unless specifically directed by a healthcare provider. Hence, taking Verapamil with food is the preferred method to ensure that the drug is absorbed properly and works effectively.