What is the recommended administration route for the dosing of Fungizone (Amphotericin B)?

The recommended administration route for Fungizone (Amphotericin B) is through intravenous infusion. This route is essential because Amphotericin B is poorly absorbed when taken orally, meaning that its therapeutic effects cannot be adequately achieved through oral administration.

Mixing Amphotericin B with dextrose 5% in water (D5W) for intravenous infusion is a common practice to provide the drug in a suitable solution that can help reduce irritation at the injection site and aid in proper dilution. This method allows for more controlled delivery of the medication directly into the bloodstream, facilitating optimal distribution throughout the body to effectively combat fungal infections.

Using Amphotericin B in a topical manner or as an oral preparation would not provide the necessary systemic exposure needed for it to be effectively therapeutic, explaining why those routes are not recommended.