What is the primary method through which nafcillin is metabolized?

Nafcillin is primarily metabolized through the liver, where it undergoes biotransformation to form inactive metabolites. This metabolic process primarily involves hepatic enzymes, which convert the drug into compounds that can be eliminated from the body.

While nafcillin is also predominantly excreted unchanged through the kidneys, this option does not capture the primary method of metabolism. After its hepatic metabolism, the resulting metabolites are then cleared from the body, primarily via renal excretion, which further emphasizes the liver's role in processing the drug. Thus, understanding the hepatic metabolism of nafcillin is crucial for grasping how the drug is cleared and how it may interact with other substances affecting liver function.