What is the primary concern when prescribing Clozaril (Clozapine)?

The primary concern when prescribing Clozaril (Clozapine) is agranulocytosis, which is a potentially life-threatening condition characterized by a dangerously low level of neutrophils in the blood. This side effect can increase the risk of serious infections due to the compromised immune system.

Clozapine is unique among antipsychotic medications due to its efficacy, especially in treatment-resistant schizophrenia. However, before initiating treatment with Clozapine, regular monitoring of white blood cell counts is mandated to ensure the patient's safety. The risk of agranulocytosis is significant enough that patients receiving Clozapine are typically enrolled in a registry to maintain a close watch on their hematological health.

While hypertension, cardiac arrhythmias, and acute renal failure can also be associated with various medications, they are not the primary risks linked to Clozapine. The severe impact of agranulocytosis necessitates careful patient selection and monitoring, making it the foremost concern in the context of prescribing this medication.