What is the prescribed dosage of Vancomycin for treating C. difficile infection?

The standard prescribed dosage of Vancomycin for treating a Clostridioides difficile infection (C. diff) is indeed 125 mg taken orally four times a day (QID) for a total duration of 10 days. This regimen is recommended because it ensures adequate drug exposure at the site of the infection, which is crucial for effectively eradicating the C. difficile bacteria from the gastrointestinal tract.

Vancomycin works by targeting the cell wall synthesis of the bacteria, leading to cell lysis and death. The four times daily dosing helps to maintain effective drug levels in the bowel and combats the high relapse rates associated with C. difficile infections when the drug is not dosed adequately.

Other dosage regimens listed fail to meet this standard due to insufficient frequency or incorrect dosing which might not achieve the desired therapeutic effect. Hence, the specific administration of 125 mg QID is critical for effective treatment in such cases.