What is the percentage of the tPa (Alteplase) dose given in the first minute?

The correct answer is that 10% of the total dose of tPA (Alteplase) should be administered in the first minute of treatment. This dosing strategy is critical because it is part of the protocol designed for the management of acute ischemic stroke. Administering this percentage in the first minute ensures that the patient receives an initial bolus of the medication that can rapidly initiate thrombolysis.

The remaining dosage is typically infused over the next hour, allowing for controlled and sustained drug delivery which maximizes the chances of reestablishing blood flow. This protocol is well-studied and forms part of standard treatment guidelines, ensuring that both safety and efficacy are considered during the administration of thrombolytic therapy.