What is the optimal peak level for Tobramycin?

The optimal peak level for Tobramycin, which is an aminoglycoside antibiotic used to treat various infections, is generally considered to be within the range of 5-10 mcg/mL. This range provides an effective balance between efficacy and reduced risk of toxicity, particularly nephrotoxicity and ototoxicity, which are important considerations when managing patients on aminoglycoside therapy.

Lower peak levels beyond this range may not be sufficient to ensure effective bacterial coverage against infections, especially against Gram-negative bacteria, which this medication targets. Higher levels in the range of 15-20 mcg/mL or above can lead to an increased risk of adverse effects without offering substantial additional benefit for most infection targets. Therefore, the 5-10 mcg/mL peak level is the clinically recommended range for balance in both effectiveness and safety.