What is the minimum nitrate-free period required when using Dilatrate-SR or Isordil?

The minimum nitrate-free period required when using Dilatrate-SR or Isordil is 14 hours. This is crucial for preventing tolerance to nitrates, which can reduce their effectiveness over time if used continuously without a break. A nitrate-free interval allows the body's physiological response to nitrates to reset, ensuring that when the medication is reintroduced, it can exert its therapeutic effects effectively.

In patients who use nitrates, particularly for angina management, maintaining this nitrate-free period is essential to maximize the medication's benefits and minimize potential side effects. Understanding this timing is important for proper patient education and medication adherence.