What is the maximum dose for tPa (Alteplase)?

The maximum dose of tPA (Alteplase) is 90 mg, which is particularly relevant in the context of administering this medication for the treatment of acute ischemic stroke. The dosing is based on the patient's weight, with the standard protocol recommending that patients receive 0.9 mg/kg, capping at a maximum dose of 90 mg. This dosing guideline ensures that patients receive an effective dose while minimizing the risk of complications, particularly intracranial hemorrhage.

Understanding the dosing is critical for healthcare providers, as exceeding recommended doses can lead to significant adverse effects, while underdosing may not provide the desired therapeutic outcome. It is important to adhere to established guidelines to ensure patient safety and effective treatment.