What is the maximum dose of Alteplase (tPA) for a patient weighing 100 kg?

The maximum dose of Alteplase (tPA) is calculated based on the patient's weight, specifically using a guideline that recommends a maximum dosage of 0.9 mg/kg for eligible patients. For a patient weighing 100 kg, this calculation would yield a maximum dose of 90 mg (0.9 mg/kg x 100 kg).

This effectively establishes that any patient weighing 100 kg should receive no more than 90 mg of Alteplase to ensure safety and efficacy, particularly in the context of treating acute ischemic stroke. The dosing is carefully calibrated to optimize therapeutic outcomes while minimizing the risk of complications such as hemorrhage.

Therefore, 90 mg is the maximum dose and aligns perfectly with the established dosing guidelines for Alteplase administration.