What is the main reason to use Mirtazapine for patients with sexual dysfunction?

Mirtazapine is often utilized for patients experiencing sexual dysfunction primarily because it serves as an alternative when Bupropion is contraindicated. Bupropion is well-known for its favorable effects on sexual function and libido, but there are instances when it may not be a suitable choice due to issues such as a history of seizures, eating disorders, or specific drug interactions.

Mirtazapine, while it has a distinct mechanism of action as a noradrenergic and specific serotonergic antidepressant (NaSSA), can also be beneficial for patients in this context. It may help manage depressive symptoms without significantly exacerbating sexual dysfunction, making it a preferred option when first-line treatments like Bupropion cannot be prescribed.

This reasoning underscores the value of Mirtazapine as a versatile treatment in the management of patients who require antidepressant therapy while also being aware of sexual function, particularly when other medications may pose a risk or are unsuitable for the individual.