What is the initial loading dose of aspirin for patients receiving dual antiplatelet therapy (DAPT) after thrombolytics in STEMI?

The initial loading dose of aspirin for patients receiving dual antiplatelet therapy (DAPT) after thrombolytics in the setting of ST-Elevation Myocardial Infarction (STEMI) is typically recommended to be between 162 mg and 325 mg. This higher dose is crucial in the acute management of STEMI as it helps to quickly inhibit platelet aggregation and reduce the risk of subsequent thrombus formation, which is essential following thrombolytic therapy. The dosing range serves to rapidly achieve effective platelet inhibition, especially in the early management phase after a myocardial infarction.

Utilizing a loading dose in this range ensures that patients receive the beneficial effects of aspirin as quickly as possible, complementing the effects of other antiplatelet agents used in conjunction, such as clopidogrel or ticagrelor, in the dual therapy regimen.