What is the drug of choice for treating Aspergillosis?

Voriconazole is the drug of choice for treating Aspergillosis due to its high efficacy against Aspergillus species, particularly in cases of invasive aspergillosis. This antifungal works by inhibiting the synthesis of ergosterol, an essential component of fungal cell membranes, which disrupts cell membrane integrity and leads to cell death.

Voriconazole has a better pharmacological profile and improved tolerance compared to other antifungals. It offers better penetration into tissues and has a broader spectrum of activity against various fungal strains compared to fluconazole and amphotericin B. While fluconazole is effective against certain fungal infections, its activity against Aspergillus is limited, making it a less ideal choice. Amphotericin B, though effective against many fungal infections, is often associated with higher toxicity and may be reserved for cases resistant to other treatments or in a rescue setting. Rifampin is primarily an antibiotic used for bacterial infections and does not have activity against fungi, rendering it irrelevant for treating Aspergillosis.