What is the advised method for taking Niacin to mitigate side effects?

Taking niacin with meals and titrating the dosage slowly is advised to mitigate side effects such as flushing, itching, and gastrointestinal discomfort. Consuming niacin with food can help reduce the intensity of these side effects, as it slows the absorption of the niacin into the bloodstream, leading to a more gradual increase in serum levels. This approach allows the body to adapt to the medication more comfortably.

Additionally, titrating the dosage slowly means starting with a low dose and gradually increasing it over time. This method helps individuals adjust to the effects of niacin and minimizes the risk of adverse reactions. By taking these precautions, patients can experience the benefits of niacin while minimizing discomfort and enhancing tolerability of the medication.