What is one off-label use of Elavil (amitriptyline)?

Elavil, or amitriptyline, is primarily known as a tricyclic antidepressant that is FDA-approved for the treatment of depression. However, it has several off-label uses that have emerged from clinical practice and research. One significant off-label use is for migraine prophylaxis.

Amitriptyline is effective in preventing migraines due to its ability to modulate neurotransmitters that play a role in pain pathways and to influence mood and anxiety, which can be related to headaches in some patients. Studies have shown that low-dose amitriptyline can reduce the frequency and intensity of migraine attacks, making it a common choice among healthcare providers for patients suffering from chronic migraines.

While amitriptyline is sometimes used for insomnia and anxiety, these uses are secondary to its primary role in managing depression and are not as well-supported by research as its use in migraine prophylaxis. Therefore, the most recognized and supported off-label application of amitriptyline is in the prevention of migraine headaches.