What is one of the serious side effects associated with Abacavir use?

Abacavir is an antiretroviral medication used to treat HIV, and one of the most significant and serious side effects associated with its use is severe allergic reactions. These reactions can manifest as symptoms such as fever, rash, gastrointestinal issues, or respiratory problems. It's notable that the risk of developing such hypersensitivity reactions is higher in individuals who have a specific genetic marker known as HLA-B*5701.

Understanding the seriousness of this side effect is crucial for healthcare providers because if a patient has a history of hypersensitivity to Abacavir, they must avoid the drug due to the potential for life-threatening outcomes. This highlights the importance of genetic testing before initiating treatment with Abacavir.

The other options listed do not align with recognized serious side effects of Abacavir. For example, while cardiotoxicity can be a concern with some medications, it is not a common side effect of Abacavir. Enhanced liver function is also not typically associated with this drug, nor is increased appetite, which is not a documented side effect of Abacavir use. Understanding these nuances is essential for appropriate patient management and education.