What is a unique characteristic of levofloxacin compared to other fluoroquinolones?

Levofloxacin is distinguished from other fluoroquinolones by its 100% bioavailability when taken orally. This means that when administered through the oral route, the entire dose of the medication enters the systemic circulation and reaches effective concentrations in the body. High oral bioavailability is crucial as it permits dose flexibility, making levofloxacin equally effective whether given orally or intravenously.

This characteristic allows for a seamless transition between intravenous and oral forms of delivery without the risk of altering the therapeutic effects due to absorption differences that may occur with other medications. Other fluoroquinolones typically have lower bioavailability, which can necessitate adjusted dosing or specific administration guidelines that levofloxacin does not require.