What is a significant side effect to monitor for when taking Bupropion (Wellbutrin)?

Bupropion, marketed as Wellbutrin, is an atypical antidepressant frequently prescribed for major depressive disorder and as a smoking cessation aid. One of the significant side effects associated with Bupropion is the risk of seizures. This risk is dose-dependent, and certain populations, such as individuals with a history of seizures or eating disorders (like bulimia or anorexia), are considered especially vulnerable. Clinicians must carefully monitor patients for seizure activity, particularly when initiating therapy or adjusting the dose.

While weight gain, cardiac arrhythmias, and excessive sleepiness can occur with other medications, Bupropion is actually noted for weight loss effects and generally does not cause sedation. Therefore, the correct option indicates a critical side effect that practitioners should be vigilant about when treating patients with Bupropion.