What is a significant side effect of calcium channel blockers?

Calcium channel blockers primarily function by relaxing the smooth muscles of blood vessels, leading to peripheral vasodilation. This mechanism is significant because it allows for increased blood flow and reduced vascular resistance, which can be beneficial in treating conditions like hypertension and angina. As peripheral blood vessels dilate, it helps in lowering the workload on the heart and can alleviate symptoms associated with cardiovascular issues.

While calcium channel blockers can influence heart rate and blood pressure, their direct action on promoting vasodilation in peripheral vessels makes it the key significant side effect. This effect allows for better management of blood pressure, making peripheral vasodilation an essential aspect of how calcium channel blockers provide therapeutic benefits.