What is a significant risk associated with the use of Busulfex (busulfan)?

Busulfex (busulfan) is a chemotherapeutic agent primarily used in conditioning regimens prior to hematopoietic stem cell transplant. One significant risk associated with its use is the occurrence of seizures, which can arise due to the neurotoxic effects of the drug. High doses of busulfan can lead to changes in the central nervous system, particularly affecting the balance of neurotransmitters and potentially precipitating seizure activity.

To mitigate this risk, patients receiving busulfan are sometimes given prophylactic anticonvulsants during treatment. Recognizing the potential for seizures is crucial for healthcare providers to monitor and manage patient safety effectively. Understanding this risk is vital for those involved in the administration and supervision of busulfan therapy.