What is a notable side effect that may appear in the nails of patients on NRTI therapy?

Patients on NRTI (Nucleoside Reverse Transcriptase Inhibitor) therapy can experience a notable side effect in their nails, specifically a purple discoloration. This phenomenon is linked to the toxicity of certain NRTIs, which can lead to various dermatological manifestations. The purple coloration can be attributed to the accumulation of the drug in the nail matrix or the effects of metabolites on the surrounding tissues.

This side effect serves as an important clinical indicator for healthcare providers when monitoring treatment and can be significant for guiding further assessments or adjustments in therapy. Understanding this side effect helps in recognizing potential complications from NRTI treatment and in providing comprehensive care to patients undergoing antiretroviral therapy.