What is a notable effect associated with the use of Spravato?

Spravato, which is an intranasal formulation of esketamine, has been shown to have notable psychoactive effects, including a sense of dissociation or feeling detached from one's body. This dissociative effect is considered a significant aspect of its mechanism of action and therapeutic profile, especially in relation to its rapid-acting antidepressant properties.

Patients may experience alterations in perception or a sense of floating, which can contribute to the overall experience of relief from depressive symptoms. This dissociative experience can be therapeutic for some individuals, as it may enable them to step back from their mental health struggles. Understanding this effect is crucial for healthcare providers in managing treatment expectations and monitoring patient experiences during the administration of Spravato.

In contrast, while energy levels and anxiety reduction can be associated with overall improvement in mood with effective antidepressants, they are not the signature effects of Spravato itself. Weight gain is typically more associated with long-term use of certain antidepressants, particularly those that are not classified in the same way as Spravato. Thus, feeling of detachment is recognized as a specific and notable effect linked to this medication.