What is a notable adverse reaction associated with Nilutamide?

Nilutamide, a nonsteroidal antiandrogen used primarily in the treatment of prostate cancer, is well-known for its association with hepatotoxicity. The liver-related adverse effects can lead to elevations in transaminases and potentially more serious outcomes such as liver failure. This hepatotoxicity can occur due to dose-related factors and idiosyncratic reactions to the drug, making it a critical aspect to monitor in patients receiving Nilutamide therapy.

While disulfiram reactions are commonly associated with a different class of drugs (like disulfiram itself or certain antibiotics), they are not a notable reaction for Nilutamide. Understanding hepatotoxicity and its implications is essential for healthcare providers when prescribing Nilutamide, ensuring they monitor appropriate liver function tests throughout treatment to mitigate the risks associated with this adverse reaction.