What is a neurologic side effect associated with prolonged steroid use?

Prolonged steroid use can lead to a variety of neurologic side effects, with central nervous system (CNS) issues being a significant concern. This category encompasses a range of problems such as mood changes, depression, anxiety, and potential cognitive dysfunction. Steroids can increase the risk of psychiatric symptoms and cognitive impairments due to their influence on neurotransmitter activity and brain structure.

While cognitive decline is a relevant consequence of prolonged steroid use, the term "CNS issues" is broader and more inclusive, covering various neurologic effects that may not solely involve cognition. Muscle spasms and chronic headaches are also linked to numerous factors but are not specifically highlighted as key neurologic side effects associated with steroids in the same way CNS issues are. Therefore, the best choice that accurately reflects a significant and recognized consequence of extended steroid therapy is the presence of CNS issues.