What is a major side effect of Eloxatin (oxaliplatin) when administered with 5-FU and leucovorin?

When Eloxatin (oxaliplatin) is administered in conjunction with 5-fluorouracil (5-FU) and leucovorin, a significant side effect to anticipate is peripheral neuropathy. This condition manifests as numbness, tingling, or pain in the hands and feet and is caused by the neurotoxic effects of oxaliplatin. Peripheral neuropathy is particularly noteworthy because it can impact the patient's quality of life and might lead to treatment modifications or dose adjustments in an attempt to manage the symptoms.

While nausea can be a common side effect of cancer treatment, it is more closely associated with 5-FU and not specifically with oxaliplatin. Severe hypotension and pulmonary fibrosis are not commonly linked to this combination of chemotherapeutic agents, making them less relevant in the context of the question. Thus, recognizing peripheral neuropathy as a major side effect provides insight into the specific toxicities related to oxaliplatin treatment.