What is a common side effect of calcium channel blockers?

Calcium channel blockers are commonly associated with peripheral edema due to their mechanism of action, which involves the relaxation of vascular smooth muscle. This relaxation leads to the dilation of blood vessels, reducing peripheral resistance and lowering blood pressure. However, this vasodilation can also result in increased capillary permeability, allowing fluid to accumulate in the surrounding tissues, particularly in the lower extremities. This accumulation of fluid manifests as swelling or edema. While other side effects can occur with calcium channel blockers, peripheral edema is particularly notable and is one of the most frequently reported adverse effects in patients using these medications.