What is a common side effect of thiazide diuretics?

Thiazide diuretics are known for their ability to promote the elimination of water and sodium from the body, primarily used in the treatment of hypertension and edema. One common side effect associated with thiazide diuretics is hypotension, which occurs due to the reduction in blood volume and vasodilation resulting from the diuretic effect. Patients may experience a drop in blood pressure, particularly when initiating therapy or increasing the dose.

While some side effects of thiazide diuretics can include elevated cholesterol levels, the more significant and clinically relevant side effect is hypotension, as it directly impacts the patient's cardiovascular status. Understanding the mechanism of action of thiazide diuretics, as well as their effects on fluid balance, can help clarify why hypotension is a common outcome of their use.