What important information should be noted when using Xarelto (Rivaroxaban)?

When using Xarelto (Rivaroxaban), an important aspect to note is that it must be taken with food when the dose is greater than 15 mg. This is crucial because taking Rivaroxaban with food helps to enhance its absorption and ensures the medication reaches effective levels in the bloodstream. For doses of 15 mg or less, the medication can be taken without consideration to food intake.

The pharmacokinetics of Rivaroxaban indicate a substantial increase in its bioavailability when taken with food, particularly at those higher doses. Therefore, adherence to this guideline is essential for maintaining optimal therapeutic levels and ensuring the drug works effectively in preventing thromboembolic events.

In contrast, other options like its method of administration (which is oral and not subcutaneous) or the settings in which it is used (applicable both in outpatient and inpatient scenarios) do not encompass this key information about dosage effectiveness related to food intake. Additionally, the claim that it can be taken with or without food does not apply when considering doses greater than 15 mg, making the first option critical for proper medication management.