What generation of cephalosporin is Fetroja (cefiderocol)?

Fetroja (cefiderocol) is classified as a novel cephalosporin that is often considered to be part of the 5th generation of cephalosporins. This generation is distinct due to its enhanced activity against a broader spectrum of bacteria, particularly including some multi-drug resistant organisms. Cefiderocol's unique structure allows it to be effective against certain types of pathogens that are typically resistant to other cephalosporins, especially Gram-negative bacteria.

It is important to note that while cefiderocol exhibits characteristics that align closely with the fifth generation, it also features a catechol moiety that facilitates iron acquisition, which is a novel mechanism not present in previous generations. This makes it particularly useful in treating infections caused by resistant strains.

The other generations of cephalosporins have different target organisms and susceptibility profiles. Third-generation cephalosporins primarily expand coverage against Gram-negative bacteria but lack some of the resistance-breaking capabilities. Fourth-generation cephalosporins have enhanced activity against Gram-negative pathogens but do not encompass the novel aspects that cefiderocol introduces. Lastly, as of the knowledge cutoff, there is no widely accepted classification of a sixth generation of cephalosporins, which means cevferidor