What effect does quinidine have on Digoxin levels?

Quinidine is known to have a significant interaction with Digoxin, a medication used to treat various heart conditions, including atrial fibrillation and heart failure. When quinidine is administered, it can inhibit the renal clearance of Digoxin, leading to increased levels of Digoxin in the bloodstream. Research indicates that this interaction can result in an increase in Digoxin levels by approximately 33-50%, which can put patients at risk for Digoxin toxicity if not monitored closely.

Understanding this interaction is crucial, especially for healthcare providers who are managing patients on these medications concurrently. The potential for elevated Digoxin levels means that monitoring is necessary to adjust dosages and ensure patient safety.

In contrast, the other choices do not reflect the well-documented pharmacological interaction between quinidine and Digoxin. The increase of 50% matches with findings in clinical studies, while options suggesting a reduction or no significant effect are not supported by the pharmacokinetic data available in the medical literature.