What effect do NSAIDs have on blood pressure?

Nonsteroidal anti-inflammatory drugs (NSAIDs) are known to have an impact on the cardiovascular system, and one of their notable effects is the potential to increase blood pressure. This occurs because NSAIDs can lead to fluid retention by inhibiting the production of prostaglandins, which are substances that help maintain kidney function and regulate blood flow. When prostaglandins are inhibited, it may result in decreased renal blood flow and subsequent sodium and water retention, leading to an increase in blood volume and, therefore, an elevation in blood pressure.

Additionally, chronic use of NSAIDs has been associated with increased blood pressure in individuals, particularly those who already have hypertension or are at risk for cardiovascular issues. Monitoring blood pressure in patients taking NSAIDs is crucial, especially in those with pre-existing heart conditions or hypertension.

This understanding emphasizes the importance of caution when prescribing NSAIDs to patients with known blood pressure issues, as it can potentially exacerbate existing conditions.