What does the Yellow Fever vaccine YF-VAX require caution with?

The Yellow Fever vaccine, YF-VAX, contains live attenuated viruses, which can trigger allergic reactions in individuals with a history of egg allergies. This is due to the vaccine production process, which typically involves chick embryo culture. Those who are allergic to eggs may have a heightened risk of experiencing anaphylaxis or other severe allergic reactions when exposed to the components of the vaccine.

Therefore, caution is advised for individuals with an egg allergy prior to vaccination, and they may need to undergo specific assessments or alternative vaccination strategies to ensure their safety. In contrast, other conditions listed, such as a history of asthma, diabetes, or recent surgeries, are not associated with the same level of concern regarding vaccine administration and adverse reactions as egg allergies are in relation to YF-VAX, allowing for a broader population to safely receive the vaccine.