What does the mnemonic S L U D G E stand for?

The mnemonic S L U D G E is primarily used to remember the signs of increased cholinergic activity, particularly in the context of medications that have anticholinergic effects. Each letter in S L U D G E corresponds to specific symptoms:

• S: Salivation

• L: Lacrimation (tear production)

• U: Urination

• D: Diarrhea

• G: Gastrointestinal distress (such as cramping)

• E: Emesis (vomiting)

Understanding this mnemonic is particularly helpful in pharmacology, especially when discussing the side effects of certain medications that antagonize acetylcholine, as these effects counteract the actions represented by S L U D G E. Anticholinergic medications often lead to dry mouth, constipation, urinary retention, and other symptoms that interfere with cholinergic functions, making S L U D G E an essential tool for identifying potential side effects stemming from underactive cholinergic responses.