What disease is primarily caused by Streptococcus pyogenes?

Streptococcus pyogenes is primarily associated with strep throat, which is a bacterial infection that leads to inflammation and pain in the throat. This bacterium is a group A streptococcus (GAS) and is known to cause pharyngitis, characterized by symptoms such as a sore throat, fever, and swollen lymph nodes.

In contrast, other options represent infections caused by different pathogens or bacteria. Sinusitis, for instance, is typically caused by various viruses or sometimes by different types of bacteria, but not specifically by Streptococcus pyogenes. Urinary tract infections are usually linked to Escherichia coli or other uropathogenic bacteria. Pneumonia, while it can be caused by streptococci, is more commonly associated with Streptococcus pneumoniae rather than Streptococcus pyogenes. Therefore, strep throat clearly stands out as the primary disease caused by this specific bacterium.