What condition can be exacerbated by glucocorticoid use due to electrolyte changes?

Glucocorticoid use can lead to electrolyte changes, particularly causing significant effects on potassium levels in the body. When glucocorticoids are administered, they increase the excretion of potassium by the kidneys, which can result in reduced potassium levels, known as hypokalemia. This condition can manifest with symptoms such as muscle weakness, fatigue, and arrhythmias.

While hypertension, osteoporosis, and diabetes can also be influenced by glucocorticoid treatment, the key aspect of this question is the direct link to electrolyte imbalances caused by the hormone. Glucocorticoids can increase sodium retention and the subsequent loss of potassium, leading to hypokalemia as a prominent issue in patients undergoing glucocorticoid therapy. This connection highlights the specific concern regarding electrolyte disturbances, making hypokalemia the most pertinent condition related to glucocorticoid use in this context.