What component does Auvelity combine with dextromethorphan to enhance its effectiveness?

Auvelity is a medication that combines dextromethorphan, an NMDA receptor antagonist and cough suppressant, with bupropion, an antidepressant that affects neurotransmitter levels in the brain. Bupropion enhances the effectiveness of dextromethorphan by acting on different pathways, particularly increasing the levels of dopamine and norepinephrine. This combined action not only provides antidepressant effects but also may contribute to improved symptoms in conditions such as major depressive disorder.

In contrast, the other options listed—amitriptyline, sertraline, and fluoxetine—are distinct medications with different mechanisms of action and are not components of Auvelity. Amitriptyline is a tricyclic antidepressant, while sertraline and fluoxetine are selective serotonin reuptake inhibitors (SSRIs). None of these would serve to enhance the effectiveness of dextromethorphan in the way that bupropion does in this specific formulation.