What combination with benzodiazepines is considered lethal according to the boxed warning?

The combination of opioids and alcohol is particularly dangerous and is highlighted in the boxed warnings for benzodiazepines. This warning emphasizes the increased risk of respiratory depression, sedation, and overdose when these substances are taken together. Both opioids and alcohol are central nervous system depressants, which means they can enhance each other's effects, leading to severe sedation and potentially fatal outcomes.

When used alongside benzodiazepines, the effects can be compounded, increasing the risk of life-threatening respiratory depression. These concerns are significant enough to warrant strong advisories against the concurrent use of these substances in clinical settings. The boxed warning serves to alert healthcare providers and patients to this critical safety information, underscoring the need for caution in prescribing and consuming these medications simultaneously.