What combination of drugs is found in Aldactazide?

Aldactazide is a medication that contains a specific combination of active ingredients. The correct answer emphasizes the presence of spironolactone and hydrochlorothiazide (HCTZ) in its formulation.

Spironolactone is a potassium-sparing diuretic that works by antagonizing aldosterone, which helps prevent the loss of potassium when diuresis is induced. Hydrochlorothiazide, on the other hand, is a thiazide diuretic that promotes the excretion of sodium and water, leading to a decrease in blood volume and subsequently lowering blood pressure. The combination of these two drugs provides a complementary effect: while hydrochlorothiazide effectively reduces fluid retention and lowers blood pressure, spironolactone helps retain potassium, minimizing the risk of hypokalemia, a common side effect of thiazide diuretics.

This combination is beneficial in treating conditions such as hypertension and edema in patients who may have a predisposition to electrolyte imbalances. Thus, the pairing of spironolactone with HCTZ in Aldactazide not only utilizes the strengths of each medication but also mitigates some of the side effects that one might experience if using a thiazide diuretic alone