What combination of drugs does Harvoni contain?

Harvoni is a direct-acting antiviral medication specifically designed for the treatment of chronic hepatitis C. The components of Harvoni are sofosbuvir and ledipasvir, which work synergistically to inhibit viral replication and promote the clearance of the virus from the body.

Sofosbuvir is a nucleotide polymerase inhibitor that interferes with the hepatitis C virus's ability to replicate its RNA, while ledipasvir is an NS5A inhibitor that blocks a protein required for the replication and assembly of the virus. This combination allows for a more effective treatment regimen with a simplified dosing schedule and improved cure rates compared to previous therapies.

The other drug combinations listed either include medications that are not part of Harvoni's formulation or ones that are used in different treatment protocols for hepatitis C. Ribavirin and interferon were commonly used in older treatment regimens but are not components of Harvoni.