What besides peripheral edema is noted for CCBs?

Calcium channel blockers (CCBs) primarily function by inhibiting calcium ions from entering cardiac and smooth muscle cells. This action results in vasodilation and a decrease in heart contractility, which can lower blood pressure and reduce the workload on the heart.

The correct choice highlights that CCBs have no significant effect on lipid or glucose metabolism. This is an important aspect of CCBs that distinguishes them from some other antihypertensive medications that may influence lipid profiles or glucose levels. Patients with conditions like hypertension, especially those with metabolic syndrome or diabetes, often require medications that do not negatively impact their lipid profiles or glucose control.

In contrast, increased cholesterol levels and severe fatigue are not typical effects associated with CCBs. While decreased heart rate can occur especially with specific types of CCBs, such as those that act primarily on the heart (like non-dihydropyridines), it is not a universal effect that represents CCBs as a class. Thus, the choice that emphasizes the lack of effect on lipid and glucose metabolism is particularly relevant for patients concerned about these issues.