What adverse effect is associated with Clindamycin?

Clindamycin is an antibiotic that can alter the normal flora of the intestines, which may lead to an overgrowth of Clostridium difficile (C. diff). This overgrowth is a significant concern because C. diff can cause severe colitis, which manifests with symptoms such as diarrhea, fever, and abdominal pain. The mechanism underlying this adverse effect occurs when Clindamycin disrupts the balance of gut bacteria, allowing C. diff to proliferate and release toxins that harm the intestinal lining. Hence, the association of Clindamycin with C. diff infection is well-documented in clinical settings, making this option the correct answer for the adverse effect related to this antibiotic. Understanding this risk is crucial for healthcare providers when prescribing Clindamycin, particularly in patients who may be at higher risk for C. diff infections, such as those with a history of antibiotic use or underlying gastrointestinal conditions.