What adverse effect can SGLT2 inhibitors have on lipids?

SGLT2 inhibitors, which are primarily used for managing type 2 diabetes, can indeed lead to some changes in lipid profiles. One notable adverse effect is the potential increase in triglyceride levels. The mechanism behind this may involve the way SGLT2 inhibitors influence fat metabolism and energy expenditure, potentially leading to lipolysis and subsequent changes in lipid levels.

While SGLT2 inhibitors generally help improve glycemic control, their impact on lipid metabolism can be variable among individuals. The increase in triglycerides can sometimes be offset by improvements in other lipid parameters, but this specific effect underscores the importance of monitoring lipid levels in patients starting these medications.

Understanding this effect is crucial for healthcare providers to manage both diabetes and lipid levels effectively when treating patients with SGLT2 inhibitors.