What adjustment is necessary when dosing Aggrastat?

For dosing Aggrastat (tirofiban), a key consideration is the patient's renal function. The drug is excreted primarily by the kidneys, meaning that impaired renal function can lead to increased plasma concentrations of the medication, which may heighten the risk of bleeding and other adverse effects. Therefore, a dose adjustment is warranted based on the patient's renal status to ensure both efficacy and safety.

By evaluating the patient's renal function, healthcare providers can modify the dosing regimen appropriately, making sure that the drug is used effectively without elevating the risk associated with its potential side effects. This adjustment is crucial in maintaining therapeutic levels while minimizing potential toxicity, thereby providing safe and effective management for patients receiving Aggrastat.