What additional requirement does Dovato have for administration?

Dovato, which is a combination of dolutegravir and lamivudine, is specifically designed for patients who have never been treated for HIV before. This is an important requirement because these medications are meant for initial therapy in treatment-naïve cases to ensure optimal effectiveness and minimize the risk of resistance developing to the drugs. If used in patients who have previously received HIV treatment, the effectiveness may be compromised, and it could lead to accelerated viral resistance.

Other choices do not align with the specific requirements for Dovato. For instance, it does not have a food requirement, nor is it mandated to be administered under strict medical supervision beyond what is standard for all medications. Additionally, while a prescription is needed, the monthly refill requirement is not uniquely applicable to Dovato compared to other medications. Understanding these specifics is essential for ensuring patients receive appropriate HIV treatment.