Retention of which substance is a side effect of prednisone?

Prednisone is a corticosteroid medication that can lead to the retention of sodium in the body. This occurs because prednisone is known to have mineralocorticoid properties, which can promote sodium reabsorption in the kidneys. As sodium is retained, it can lead to increased fluid retention, which may cause swelling, elevated blood pressure, and changes in electrolyte balance.

In contrast, other substances like potassium, calcium, and magnesium are typically affected in a negative way due to the use of prednisone. For instance, prednisone can promote the excretion of potassium, leading to hypokalemia, and it can also negatively impact calcium and magnesium levels, contributing to bone density loss and muscle weakness. Therefore, recognizing sodium retention as a side effect is crucial in managing potential complications associated with the use of prednisone.