Mirtazapine is associated with which common side effect?

Mirtazapine, an antidepressant commonly used to treat major depressive disorder, is notably associated with weight gain as a common side effect. This occurs due to several mechanisms; one of the most significant is its antagonistic action on certain serotonin receptors (5-HT2C) and its influence on histamine receptors (H1). These actions can lead to increased appetite and cravings for carbohydrates, often resulting in significant weight gain.

Patients on mirtazapine frequently report a noticeable increase in appetite and subsequent weight gain, which can be a key consideration when prescribing this medication. While other side effects like nausea, dry mouth, and insomnia can occur, they are not as commonly associated with mirtazapine as weight gain is. This characteristic makes mirtazapine a unique agent, as its side effects can have substantial implications for a patient's overall health and treatment plan.