In which scenario is Descovy contraindicated?

Descovy, a medication used for HIV pre-exposure prophylaxis (PrEP), is contraindicated in individuals with a creatinine clearance lower than 30 mL/min. This is primarily due to the risk of renal toxicity associated with the drug. When kidney function is significantly impaired, the body may not adequately clear the medication, leading to potentially harmful levels in the system. As a safety precaution, prescribing Descovy in such cases would not be advisable to prevent adverse side effects.

The criteria for use in other options do not indicate a direct contraindication. For instance, having a CD4 count below 200 is not a direct reason for contraindication, as it is related more to the management of HIV rather than to the use of Descovy for PrEP. Similarly, a history of previous treatments does not automatically disqualify an individual from using Descovy, nor is it relevant to kidney function or safety. Lastly, while Descovy is targeted for specific populations engaged in certain sexual activities, not engaging in anal sex does not constitute a contraindication for its use.