In which case should the dosage of Gabapentin be adjusted?

Gabapentin is primarily eliminated by the kidneys, making renal clearance a critical factor in determining the appropriate dosage for patients. When there is compromised renal function, the body is less able to excrete the drug, which can lead to increased plasma levels and a higher risk of side effects or toxicity. Therefore, dosage adjustments must be made based on the patient's renal function, often determined by creatinine clearance or estimated glomerular filtration rate (eGFR).

While hepatic clearance, gastrointestinal absorption, and metabolic clearance are also important considerations in pharmacology, they do not directly affect Gabapentin in the same way as renal clearance does. Gabapentin does not require dosage adjustments for mild to moderate hepatic impairment, and its absorption is relatively consistent regardless of gastrointestinal function. Moreover, Gabapentin is not significantly metabolized by the liver, which further emphasizes the importance of monitoring renal function. This understanding is essential for safe and effective medication management in patients prescribed Galbatentin.