How often should ANC be monitored for a patient starting on Clozapine?

For a patient starting on Clozapine, monitoring the Absolute Neutrophil Count (ANC) is crucial due to the risk of agranulocytosis associated with the medication. Research guidelines recommend that ANC should be monitored weekly for the first six months of treatment. This close monitoring is essential as it helps to detect any drop in neutrophil levels early, allowing for prompt intervention if necessary.

After the initial six-month period, if the ANC remains stable and within safe limits, the monitoring frequency may be adjusted. However, for this initial phase, the weekly checks are vital to ensure patient safety and manage the risks effectively. Thus, the recommendation for ANC monitoring every week for the first six months is appropriate and reflects best practices in patient care while on Clozapine.